Summaries by Inventor Edelson, Brian

Bhlhe40 flox/flox mice
Edelson, Brian
T-019054

— The Bhlhe40 flox/flox mice on the C57BL/6 background originated as a KO-first promoter-driven mouse line from the Knockout Mouse Project and were purchased from the Jackson Laboratory. These initial mice contained a Bhlhe40 allele with a splice acceptor-LacZ reporter and a Neo cassette flanked by tw…

Targeting B Cells for Antibody-Mediated Graft Rejection
Edelson, Brian ; Fremont, Daved ; Liu, Chang ; Nelson, Christopher ; Wang, Xiaoli
T-018682

— Disease Indications Drug type: Biologic – engineered protein Drug class: First in class Technology: A recombinant fusion protein that depletes B cells in the recipient that are specific to the donor HLA. The fusion protein offers a targeted therapy for antibody-mediated rejection in the …